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. 2021 Nov 16;40:364. doi: 10.1186/s13046-021-02154-8

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© The Author(s) 2021, corrected publication 2022

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Fig. 2 — Viability and proliferation in HCC cells after treatment with different combination of TAE226 and SOR. A Scheme of the experimental design. B Cell viability was expressed as fold change of absorbance values by XTT assay, in HepG2 and Huh7 cells treated vs. NT. Values are the mean OD ± SD of three independent experiments repeated at least in triplicate. Data were analysed by 2-tailed Student’s t test. ***p < 0.001. C Combination Index (CI) was calculated by the Chou-Talalay method. Data plotted are CI at 50, 70, 95 and 99% fraction killed. D Cell proliferation was expressed as fold change of Europium (Eu) counts of BrdU incorporation in HepG2 and Huh7 cells treated vs. NT. Values are the mean Eu counts ± SD of three independent experiments repeated at least in triplicate. Data were analysed by 2-tailed Student’s t test. ***p < 0.001