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. 2021 Nov 16;40:364. doi: 10.1186/s13046-021-02154-8

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© The Author(s) 2021, corrected publication 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Effects of FAK inhibition on its nuclear interactome. A PPI networks of the nuclear FAK interactors. B Representative immunoblot of nuclear extracts immunoprecipitated with antibody against FAK and then immunoblotted with FAK, HDAC1, and HDAC2 antibodies in HCC cells silenced or not for FAK and in MOCK (upper panels); representative immunoblot of nuclear extracts immunoprecipitated with antibody against FAK and then immunoblotted with pTyr397FAK, HDAC1 and HDAC2 antibodies in NT or TAE226 > SOR HCC cells, and in MOCK (lower panels). The experiments were repeated in duplicate (C) Quantitative imaging of immunofluorescence for pTyr397FAK, β-Catenin, HDAC1 and HDAC2 represented as fold change of mean fluorescence intensity in HepG2 and Huh7 cells treated vs. NT. Data were analysed by 2-tailed Student’s t test. ***p < 0.001 vs. NT. D H3K27ac levels measured by AlphaLISA assay and represented as fold change in HepG2 and Huh7 cells treated vs. NT. E Graphical abstract reporting the interaction of FAK with NuRD complex