Table 1.
Patient characteristics
| Characteristic | LGG | HGG | Total | P** | |||
|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | n | (%) | ||
| Patients | 8 | (21) | 30 | (79) | 38 | (100) | |
| Slides* | 162 | (20) | 652 | (80) | 814 | (100) | |
| Age (years) | 0.056 | ||||||
| Mean (SD) | 42 | (7.52) | 50.23 | (11.07) | 48.5 | (10.87) | |
| Median (IQR) | 41 | (38–48.75) | 54 | (46.75–56.25) | 50.5 | (44.5–55) | |
| Gender | 0.709 | ||||||
| Male | 5 | (63) | 16 | (53) | 21 | (55) | |
| Female | 3 | (38) | 14 | (47) | 17 | (45) | |
| Tumor grade | < 0.001 | ||||||
| Grade II | 8 | (100) | 0 | (0) | 8 | (21) | |
| Grade III | 0 | (0) | 17 | (57) | 17 | (45) | |
| Grade IV | 0 | (0) | 13 | (43) | 13 | (34) | |
| Histologic tumor size (cm) | 0.126 | ||||||
| Mean (SD) | 2.94 | (1.03) | 3.72 | (1.31) | 3.56 | (1.29) | |
| Median (IQR) | 2.76 | (2.27–3.65) | 3.96 | (2.69–4.72) | 3.65 | (2.43–4.67) | |
| Histologic PTBE size (cm) | < 0.001 | ||||||
| Mean (SD) | 1.00 | (0.45) | 2.22 | (0.54) | 1.96 | (0.72) | |
| Median (IQR) | 1.15 | (0.48–1.35) | 2.12 | (1.84–2.86) | 2.00 | (1.45–2.43) | |
| Contrast enhancement | < 0.001 | ||||||
| Yes | 0 | (0) | 30 | (100) | 30 | (79) | |
| No | 8 | (100) | 0 | (0) | 8 | (21) | |
| Lesion site | 0.860 | ||||||
| Frontal lobe | 5 | (63) | 16 | (53) | 21 | (55) | |
| Temporal lobe | 2 | (25) | 11 | (37) | 13 | (34) | |
| Occipital lobe | 1 | (13) | 3 | (10) | 4 | (11) | |
| MGMT methylation status | 0.426 | ||||||
| Unmethylated | 5 | (63) | 12 | (40) | 17 | (45) | |
| Methylated | 3 | (38) | 18 | (60) | 21 | (55) | |
| IDH mutation | 0.698 | ||||||
| Mutated | 4 | (50) | 12 | (40) | 16 | (42) | |
| Wild type | 4 | (50) | 18 | (60) | 22 | (58) | |
| 1p/19q co-deletion | 0.689 | ||||||
| Co-deleted | 2 | (25) | 11 | (37) | 13 | (34) | |
| Non-co-deleted | 6 | (75) | 19 | (63) | 25 | (66) | |
Abbreviation: LGG low-grade glioma; HGG high-grade glioma; SD standard deviation; IQR interquartile range; PTBE peritumoral brain edema; MGMT O6-methylguanine-DNA-methyltransferase; IDH isocitrate dehydrogenase; 1p/19q co-deletion, the co-deletion of chromosome arms 1p and 19q
*Number of slides presenting this criterion
**P value according to the Student’s t-test or Fisher's exact test