Table 6.
Variables associated with ME distance in univariate and multivariate linear regression model
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | VIF | |
| Age (years) | 0.004 (−0.014 to 0.021) | 0.652 | |||
| Gender | |||||
| Male/female | 0.150 (−0.225 to 0.526) | 0.421 | |||
| Tumor grade | |||||
| LGG/HGG | 0.884 (0.532–1.236) | < 0.001 | 0.822 (0.584–1.060) | < 0.001 | 1.078 |
| Histologic tumor size (cm) | 0.092 (−0.053 to 0.237) | 0.208 | |||
| Histologic PTBE size (cm) | 0.199 (−0.056 to 0.454) | 0.122 | |||
| Tumor location | |||||
| Frontal lobe | Ref. | Ref. | |||
| Temporal lobe | −0.133 (−0.528 to 0.261) | 0.497 | |||
| Occipital lobe | −0.388 (−0.987 to 0.212) | 0.198 | |||
| Molecular markers | |||||
| MGMT methylation status | |||||
| Unmethylated/Methylated | 0.456 (0.110–0.802) | 0.011 | 0.259 (0.066–0.453) | 0.010 | 1.060 |
| IDH mutation | |||||
| Mutated/wild type | 0.617 (0.298–0.936) | < 0.001 | 0.391 (0.168–0.613) | 0.001 | 1.382 |
| 1p/19q co-deletion | |||||
| Co-deleted/non-co-deleted | 0.472 (0.109–0.836) | 0.012 | 0.300 (0.066–0.534) | 0.013 | 1.412 |
Abbreviation: ME microscopic extension; β regression coefficient; CI confidence interval; VIF variance inflation factor; LGG low-grade glioma; HGG high-grade glioma; PTBE peritumoral brain edema; MGMT O6-methylguanine-DNA-methyltransferase; IDH isocitrate dehydrogenase; 1p/19q co-deletion the co-deletion of chromosome arms 1p and 19q