Figure 2.

Estimated body weight-normalized eculizumab exposure parameters for the total patient population, Asian, non-Asian, Japanese, and non-Japanese patients. Results are shown for parameters at steady state: (A) AUC, (B) C_max, and (C) C_trough. Exposures were normalized by body weight using the exponent estimated in the final model. AUC, area under the concentration–time curve within one dosing interval; C_max, peak concentration; C_trough, concentration at the end of the dosage interval; ss, steady state.