Table 2.
Summary of estimated pharmacokinetic parameters.
| Statistic | Mean | SD | Median | 2.5th percentile | 97.5th percentile | Minimum | Maximum |
|---|---|---|---|---|---|---|---|
| CL (L/h) | 0.00759 | 0.00313 | 0.00668 | 0.00418 | 0.0154 | 0.00362 | 0.0204 |
| V1 (L) | 2.33 | 0.527 | 2.21 | 1.58 | 3.4 | 1.56 | 3.68 |
| V2 (L) | 2.11 | 0.367 | 2.06 | 1.56 | 2.9 | 1.49 | 3.09 |
| Q (L/h) | 0.238 | 0.0638 | 0.226 | 0.148 | 0.382 | 0.138 | 0.42 |
| Cmax, ss (μg/ml) | 928 | 241 | 898 | 525 | 1,380 | 453 | 1,530 |
| Ctrough, ss (μg/ml) | 405 | 152 | 416 | 140 | 706 | 92.7 | 811 |
| Terminal half-lifea (h) | 414b | 103 | 438 | 238 | 641 | 202 | 765 |
| AUCss (μg·h/ml) | 180,000 | 57,900 | 180,000 | 77,900 | 287,000 | 58,700 | 331,000 |
| Accumulation ratio | 2.06 | 0.381 | 2.05 | 1.32 | 2.8 | 1.19 | 3.28 |
Data are summaries of the individual Bayesian estimates.
a
Terminal half-life was calculated as: (V1 + V2)/CL ,100 ln(2).
b
Terminal half-life mean was calculated as harmonic mean.
AUC, area under the concentration–time curve within one dosing interval; CL, clearance; Cmax, peak concentration; Ctrough, concentration at the end of the dosage interval; Q, intercompartmental clearance; SD, standard deviation; ss, steady state; V1, volume of distribution in the central compartment; V2, volume of distribution in the peripheral compartment.