TABLE 1.
Recently published patents of benzimidazole derivatives.
| Sl. No | Patent No | Country | Patent title | Publication date | Current status | Inventors | Brief description |
|---|---|---|---|---|---|---|---|
| 1 | ES2807191T3 Berrebi-Bertrand et al. (2021) | Spain | Benzimidazole derivatives as dual ligands of the histamine H1 receptor and the histamine H4 receptor | Feb 22, 2021 | Active | Isabelle Berrebi-Bertrand, Xavier Billot, Thierry Calmels, et al | The compounds are supposed to have pharmaceutically acceptable salt, tautomers, hydrates, and solvation properties |
| 2 | AU2017382436A1 Crew et al. (2021) | Australia | Compounds and methods for the targeted degradation of Rapidly Accelerated Fibrosarcoma polypeptides | Jan 28, 2021 | Active | Andrew P. Crew, Craig M. Crews, Hanqing Dong et al | The compound showed a wide range of biological activities by inhibition/degradation of target protein |
| 3 | US10835488B2 Pevzner and Moses-Heller (2020) | United States | Stable orally disintegrating pharmaceutical compositions | Nov 17, 2020 | Active | Victor Pevzner, Sheera Moses-Heller | The composition has proton pump inhibition property |
| 4 | US10787420B2 Liu et al. (2020) | United States | Benzimidazole compound and preparation method thereof | Sep 29, 2020 | Active | Xuejing Liu, Ying Han, Liang Yang | Several benzimidazoles have been synthesized through SN2 and cyclization reactions by utilizing no toxic reagent and/or any metal catalyst |
| 5 | US20190322671A1 Bourque and Skerlj (2019) | United States | Cxcr4 inhibitors and uses thereof | Oct 24, 2019 | Pending | Elyse Marie Josee Bourque, Renato Skerlj | Data supported that the inventions have been regarded as CXCR4 blockers and healers of many diseases induced by the receptors |
| 6 | CA3079081A1 Bartberger et al. (2019) | Canada | Benzimidazole derivatives and their uses | April 25, 2019 | Pending | Michael D. Bartberger, Nagasree Chakka, Hua Gao, et al | The inventions have been considered as Transient Receptor Potential Channel 6 (TRPC6) protein inhibitors |
| 7 | AU2020104192A4 Adak et al. (2018) | Australia | Process of synthesis of benzimidazole derivatives against M.tb | Dec 20, 2018 | Active | Vishal Sudam Adak, Pravin Baburao Awate, Vishwas Chandrakant Bhagat, et al | The present invention have been disclosed as inhibitors of M.tb (H37Rv strain/ATCC No- 27294) |
| 8 | WO2018057810A1 Chandrasekhar et al. (2018) | France | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors | Mar 29, 2018 | NA | Jayaraman Chandrasekhar, Stephane Perreault, Leena Patel | The present compounds are acceptable salts, isomers, or a mixture thereof, which showed efficacy against various conditions of inflammation and cancer |
| 9 | US8372987B2 Kolaczkowski (2013) | United States | 2-{(R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide crystalline form 1 | Sep 13, 2013 | Active | Lawrence, Kolaczkowski | The present invention has notable application in facilitating DNA repair and controlling RNA transcription |
| 10 | US20150361032A1 Pajouhesh et al. (2015) | United States | Benzimidazole inhibitors of the sodium channel | Dec 17, 2015 | Active | Hassan Pajouhesh Richard Holland, Lingyun Zhang, et al | The current patent represents benzimidazole derivatives that showed inhibition of voltage gated sodium channel, which might be promising in the treatment of various diseases and conditions |
| 11 | US 20150336967A1 Czardybon et al. (2015) | United States | Novel Benzimidazole Derivatives as Kinase Inhibitors | Nov 26, 2015 | Active | Wojciech, Czardybon,Kraków Brzózka, Michal¸ Galezowski, et al | The patent describes benzimidazole derivatives as serine/threonine and tyrosine kinase-inhibitors with useful application in the treatment of solid tumors, lymphomas, leukaemia, and autoimmune disorders |
| 12 | US 20150322065A1 Chappie et al. (2015) | United States | Azabenzimidazole Compounds | Nov 12, 2015 | Active | Thomas Allen Chappie, Patrick Robert Verhoest, Nandini, Chaturbhai Patel, Matthew Merrill Hayward | The present invention depicts the role of azabenzimidazole derivatives in the treatment of metabolic, central nervous system (CNS), autoimmune and inflammatory disorders |
| 13 | US 20150307479A1 Kuduk et al. (2015) | United States | Cyclobutyl benzimidazoles as pde 10 inhibitors | Oct 29, 2015 | Active | Scott D. Kuduk, Casey C. McComas, Thomas S. Reger | The patent describes the usefulness of cyclobutyl benzimidazole derivatives in treating CNS disorders related to phosphodiesterase 10 (PDE10) |
| 14 | US 20150265625A1 Brown and Matthews (2015) | United States | (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases | Sep 24, 2015 | Active | S. David Brown, David J. Matthews | The current invention has useful application as drugs or agents in the treatment of proliferative diseases |
| 15 | US 20150218149A1 Apgar et al. (2015) | United States | Novel benzimidazole tetrahydrofuran derivatives | Aug 06, 2015 | Active | James M. Apgar, Tesfaye Biftu, Ping Chen, Danqing Feng, Jacqueline D. Hicks, et al | The present invention suggests that novel benzimidazole tetrahydrofuran derivatives are effective against diseases mediated by the AMPK-activated protein kinase |
| 16 | US 20150209259A1 Schade et al. (2015) | United States | Octocrylene-free sunscreen composition with low stickiness | July 30, 2015 | Active | Tatjana Schade, Kerstin Skubsch, Sina Brinkmann, et al | The present invention suggests an octocrylene-free cosmetic sunscreen composition which has low stickiness |
| 17 | US 20150203455A1 Menet et al. (2015) | United States | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders | July 23, 2015 | Active | Christel Jeanne, Marie Menet, Oscar Mammoliti, Javier Blanc, et al | The patent describes novel benzimidazole derivatives in treating and preventing a number of inflammatory, autoimmune and proliferative disorders |
| 18 | US 20150175608A1 Tahri et al. (2015) | United States | Novel 4-substituted 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents | June 25, 2015 | NA | Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-marie Bernard, Raboisson, et al | The compounds have useful application as antiviral agents against respiratory syncytial virus (RSV) |
| 19 | US 20150175600A1 Atkinson et al. (2015) | United States | 2-(azaindol-2-yl)benzimidazoles as pad4 inhibitors | June 25, 2015 | Active | Stephen John, Atkinson, Michael David, Barker, Matthew, Campbell, et al | The patent describes the derivatives as PAD4 inhibitors with application against cystic fibrosis, rheumatoid arthritis, systemic lupus erythematosus, cancer, ulcerative colitis, asthma |
| 20 | US 20150158878A1 Leban and Zaja (2015) | United States | Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmune inflammation and cns disorders | Jun 11, 2015 | Active | Johann Leban, Mirko Zaja | The compounds are kinase inhibitors with notable role in the treatment of autoimmune inflammation, CNS disorders and cancer |