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. 2021 Nov 17;19:364. doi: 10.1186/s12951-021-01107-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Cellular uptake of artificial exosomes and the nanoparticles induced epigenetic regulation. A CLSM analysis of the cellular uptake of EMF. B Live/Dead analysis of LLC cells treated with different formulations; C Apoptosis of LLC cells treated with different formulations; D The quantitative analysis of apoptosis of LLC cells (n = 3); E Western blotting analysis of LLC cells treated with different formulations; F RNA-Seq analysis of EMS treatment; G GO analysis of EMS treatment; H KEGG analysis of EMS treatment. The cell membranes were stained with DiL. EMF, EM/SUC/FITC. The data were represented as Mean ± SD. The statistical significance was calculated via one-way ANOVA with a Tukey post-hoc test. *P < 0.05; ****P < 0.0001