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. 2021 Nov 17;22:828. doi: 10.1186/s12864-021-08129-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Fitness effects of CFG sets across cell lines. A. Median percentage of cell lines in which the genes in the predicted sets or core-fitness gene (CFG) or common-essential gene (CEG) sets are significantly essential. B. Threshold of minimal number of dependent cell lines n required by the baseline daisy model predictor (DM) to attain the true positive rates (TPRs) observed across tested methods. C. Ratios between median numbers of dependent cell lines for predicted sets divided by the threshold n of the DM to attain their TPRs. D. Median fitness effect exerted by the genes in the predicted CFG/CEG sets. E. Ratio between the median fitness effect in D and the median fitness effect exerted by the DM at the observed TPRs. F. Ratio between the number of genes in the predicted sets and those predicted by the DM at the observed TPRs