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. 2021 Nov 17;12:61. doi: 10.1186/s13293-021-00405-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Interacting mRNA networks of all altered miRNAs. A, B A list of all 11 miRNAs altered in FGR was uploaded to miRNET and A networks of interacting genes (pink circles) associated with altered miRNAs (blue square) were determined. B Functional enrichment analysis of network genes was performed using Reactome, GO and KEGG. Key functional effects associated with the network were found in pathways associated with cellular response to stress (red; 77 node genes; Adj p = 4.9 × 10^–6), cell proliferation (yellow; 111 node genes; Adj p value = 0.00012) and vascular development (turquoise; 97 node genes; Adj p value = 0.00037)