Table 2.
Relationship between CXCR4 expression and clinico-morphological parameters
|
Clinico-morphological parameters |
No. of cases (n) |
Low IRS CXCR4 cases n (%) |
High IRS CXCR4 cases n (%) |
χ2 value |
p value |
|
Tumor location |
|
|
|
|
|
|
Stomach |
10 |
6 (60) |
4 (40) |
Non-valid |
|
|
Small intestine |
12 |
8 (66.7) |
4 (33.3) |
||
|
Appendix |
6 |
6 (100) |
0 (0) |
||
|
Right colon |
11 |
5 (45.5) |
6 (54.5) |
||
|
Left colon (including rectum) |
13 |
6 (46.2) |
7 (53.8) |
||
|
Hepatic metastasis |
19 |
9 (47.4) |
10 (52.6) |
||
|
Tumor grade |
|
|
|
|
|
|
G1 |
28 |
21 (75) |
7 (25) |
7666.2 |
0.0216 |
|
G2 |
21 |
11 (52.4) |
10 (47.6) |
||
|
G3 |
22 |
8 (36.4) |
14 (63.6) |
||
|
Tumor type |
|
|
|
|
|
|
G1 NET |
27 |
20 (74.1) |
7 (25.9) |
8057.5 |
0.1531 |
|
G2 NET |
18 |
9 (50) |
9 (50) |
||
|
G3 NET |
7 |
3 (42.9) |
4 (57.1) |
||
|
NEC |
12 |
4 (33.3) |
8 (66.7) |
||
|
MiNEN |
3 |
1 (33.3) |
2 (66.7) |
||
|
AGCC |
4 |
3 (75) |
1 (25) |
||
|
Tumor stage |
|
|
|
|
|
|
I–II |
17 |
14 (82.4) |
3 (17.6) |
6012.1 |
0.0142 |
|
III–IV |
44 |
21 (47.7) |
23 (52.3) |
||
|
Regional lymph nodes |
|
|
|
|
|
|
pN0 |
19 |
8 (42.1) |
11 (57.9) |
0.0382 |
0.8450 |
|
pN1 |
23 |
9 (39.1) |
14 (60.9) |
||
|
Lympho-vascular invasion |
|
|
|
|
|
|
Absent |
17 |
14 (82.4) |
3 (17.6) |
6178.1 |
0.0129 |
|
Present |
25 |
11 (44) |
14 (56) |
||
|
Perineural invasion |
|
|
|
|
|
|
Absent |
28 |
19 (67.9) |
9 (32.1) |
2421.1 |
0.1197 |
|
Present |
14 |
6 (42.9) |
8 (57.1) |
AGCC: Adenocarcinoma ex-goblet cell carcinoid; χ2: Chi-squared; CXCR4: C-X-C motif chemokine receptor 4; G: Grade; IRS: Immunoreactivity score; MiNEN: Mixed neuroendocrine non-neuroendocrine neoplasm; NEC: Neuroendocrine carcinoma; NET: Neuroendocrine tumor