Table 2.

Variants segregating and nonsegregating with the disease in the monozygotic twins and the JOAG patient

	Monozygotic twins	JOAG patient
Segregating with disease
Total variants	n=548	n=695
Glaucoma associated	n=1 (NF1 gene)*	n=1 (PAX6 gene)**
Nonsegregating with disease
Total variants	n=2174	n=1195
Glaucoma associated	n=0	n=1 (OPTN gene)***

*NF1 (neurofibromin 1) gene, rs191111884 an intronic variant (ClinVar: Benign). **PAX6 (paired box 6) gene, rs759391101 an inframe deletion (ClinVar: Benign). ***OPTN (optineurin) gene, rs71492279 an intronic variant (ClinVar: Benign)