Table 2.
Associations of predictor variables with global cognitive decline slope
| Unadjusted | Adjusted for age, sex, education, APOE*4, mCES-D score, WHR, and SBP | |||||
|---|---|---|---|---|---|---|
| Variable | Coef | 95% CI | p | Coef | 95% CI | p |
| age | −0.379 | (−0.462, −0.295) | <0.001 | |||
| female sex | 0.041 | (−0.150, 0.232) | 0.673 | |||
| education >HS | 0.212 | (0.033, 0.391) | 0.020 | |||
| APOE*4 carriage | −0.346 | (−0.581, −0.112) | 0.004 | |||
| mCES-D score | −0.131 | (−0.220, −0.042) | 0.004 | |||
| BMI | 0.067 | (−0.012, 0.147) | 0.096 | |||
| WHR | 0.009 | (−0.073, 0.090) | 0.835 | |||
| SBP | −0.017 | (−0.099, 0.065) | 0.682 | |||
| CRP | −0.009 | (−0.099, 0.081) | 0.846 | |||
| glucose | −0.031 | (−0.121, 0.060) | 0.505 | −0.055 | (−0.140, 0.030) | 0.206 |
| HbA1c | −0.034 | (−0.126, 0.058) | 0.469 | −0.093 | (−0.179, −0.008) | 0.033 |
| insulin | 0.045 | (−0.047, 0.136) | 0.337 | −0.001 | (−0.086, 0.083) | 0.974 |
| HOMA-IR | 0.026 | (−0.065, 0.118) | 0.574 | −0.020 | (−0.105, 0.066) | 0.652 |
| resistin | 0.009 | (−0.082, 0.099) | 0.851 | −0.011 | (−0.093, 0.071) | 0.791 |
| adiponectin | −0.098 | (−0.188, −0.008) | 0.032 | −0.008 | (−0.091, 0.076) | 0.860 |
| GLP-1 | −0.050 | (−0.146, 0.046) | 0.307 | −0.041 | (−0.124, 0.042) | 0.333 |
Note: Laboratory assay variables (CRP, glucose, HbA1c, insulin, HOMA-IR, resistin, adiponectin, GLP-1) were first natural log-transformed; then these and other quantitative variables (age, mCES-D score, BMI, WHR, SBP, global cognitive decline slope) were standardized to have mean zero and unit standard deviation.
Abbreviations: Coef: coefficient, CI: confidence interval, HS: high school, mCES-D: Modified Center for Epidemiology Depression Scale, BMI: body mass index, WHR: waist-hip ratio, SBP: systolic blood pressure, CRP: C-reactive protein, HbA1c: hemoglobin A1c, HOMA-IR: Homeostatic Model Assessment of Insulin Resistance, GLP-1: glucagon-like peptide-1.