Table 4.
Association between composite adverse perinatal outcome and umbilicocerebral ratio (UCR) ≥ 90th percentile or cerebroplacental ratio (CPR) < 10th percentile at inclusion, adjusted for gestational age at measurement (GA), estimated fetal weight multiples of the median (EFW MoM) and pre‐eclampsia, in 856 pregnancies at risk for late‐onset preterm fetal growth restriction, using different published reference charts
| Study | Ratio assessed | aOR (95% CI) | AUC (95% CI) |
|---|---|---|---|
| Arduini (1990) 19 | UCR | 2.7 (1.4–5.1) | 0.73 (0.67–0.78) |
| Baschat (2003) 20 | CPR | 2.2 (1.4–3.5) | 0.73 (0.67–0.78) |
| Ebbing (2007) 21 | CPR | 1.7 (1.1–2.7) | 0.71 (0.65–0.77) |
| Morales‐Rosello (2015) 22 | CPR | 2.3 (1.4–3.8) | 0.72 (0.66–0.78) |
| Srikumar (2017) 26 | CPR | 1.7 (1.0–2.7) | 0.71 (0.66–0.77) |
| Ciobanu (2019) 23 | CPR | 2.2 (1.4–3.6) | 0.72 (0.66–0.78) |
| Dias (2019) 27 | CPR | 2.6 (1.6–4.3) | 0.73 (0.67–0.78) |
| Flatley (2019) 25 | CPR | 2.2 (1.4–3.5) | 0.72 (0.66–0.78) |
| Zohav (2019) 28 | CPR | 2.4 (1.3–4.4) | 0.73 (0.67–0.78) |
| Acharya (2020) 24 | CPR | 1.7 (1.0–2.6) | 0.71 (0.65–0.77) |
| Adjustment parameters | |||
| GA (in weeks) | — | 0.8 (0.7–1.0) | — |
| EFW MoM | — | 0.6 (0.4–0.7) | — |
| Pre‐eclampsia | — | 2.1 (1.2–3.7) | — |
Only first author's name is given for each study.
At a sensitivity of 70%, specificity was approximately 60% for all models.
aOR, adjusted odds ratio; AUC, area under receiver‐operating‐characteristics curve.