Table 5.
Association between composite adverse perinatal outcome and umbilicocerebral ratio (UCR) or cerebroplacental ratio (CPR) multiples of the median (MoM) at inclusion (as a continuous variable), adjusted for gestational age at measurement (GA), estimated fetal weight (EFW) MoM and pre‐eclampsia, in 856 pregnancies at risk of late‐onset preterm fetal growth restriction, using different published reference charts
| Study | Adjusted OR (95% CI) | AUC (95% CI) | |
|---|---|---|---|
| UCR MoM | CPR MoM | ||
| Arduini (1990) 19 | 1.74 (1.04–2.90) | 0.45 (0.21–0.98) | 0.71 (0.66–0.77) |
| Baschat (2003) 20 | 1.58 (1.04–2.41) | 0.38 (0.15–0.97) | 0.71 (0.66–0.77) |
| Ebbing (2007) 21 | 1.51 (1.03–2.22) | 0.34 (0.12–0.96) | 0.71 (0.66–0.77) |
| Morales‐Rosello (2015) 22 | 1.62 (1.04–2.52) | 0.39 (0.16–0.97) | 0.71 (0.66–0.77) |
| Srikumar (2017) 26 | 1.60 (1.04–2.47) | 0.38 (0.15–0.97) | 0.71 (0.66–0.77) |
| Ciobanu (2019) 23 | 1.63 (1.04–2.56) | 0.40 (0.16–0.97) | 0.71 (0.66–0.77) |
| Dias (2019) 27 | 1.46 (1.02–2.09) | 0.33 (0.11–0.90) | 0.71 (0.66–0.77) |
| Flatley (2019) 25 | 1.59 (1.04–2.45) | 0.38 (0.15–0.97) | 0.71 (0.66–0.77) |
| Zohav (2019) 28 | 1.60 (1.04–2.47) | 0.38 (0.15–0.95) | 0.71 (0.66–0.77) |
| Acharya (2020) 24 | 1.53 (1.03–2.26) | 0.35 (0.13–0.96) | 0.71 (0.66–0.77) |
| Adjustment parameters | |||
| GA (in weeks) | 0.86 (0.73–0.99) | — | |
| EFW MoM | 0.54 (0.41–0.71) | — | |
| Pre‐eclampsia | 2.27 (1.33–3.86) | — | |
Only first author's name is given for each study.
At a sensitivity of 70%, specificity was approximately 60% for all models.
For assessment of CPR, the UCR charts of Arduini and Rizzo 19 were transformed (1/UCR); all other charts were for CPR and were transformed (1/CPR) for assessment of UCR.
AUC, area under receiver‐operating‐characteristics curve; OR, odds ratio.