Table 4.

Definitive Antibiotic Therapy Switch in Propensity-Matched EIE Patients Initially Treated With Ampicillin-Ceftriaxone or Ampicillin-Gentamicin

	AC (n = 49)a	AG (n = 49)a	P Value
No. of patients with therapy switch (%)	5 (10)	24 (49)	<.0001
Duration of AC or AG therapy before switch,b d	13 (3–19)	11 (7–24)	.55
Reason for switch,c No.
Adverse event	4	12
Treatment failure	0	1
Other	1	11
Unknown	0	3

Abbreviations: AC, ampicillin-ceftriaxone; AG, ampicillin-gentamicin; EIE, enterococcal infective endocarditis.

^aMissing data for 7 patients in each matched group.

^bValues are median (interquartile range).

^cSeveral patients had multiple documented reasons for switching definitive antibiotic therapy.