Figure 1.

Maximum-likelihood phylogenetic trees of 142 global CV-A6 variants constructed based on the (A) P1 capsid region and (B) noncapsid region; the lineages are differentiated by distinct colors, which are indicated in the bottom left, and each subtype is indicated on the right side of the P1 tree. The branches in each phylogeny are colored according to lineage. (C) Intralineage pairwise similarity comparison based on ORF sequences computed between each sequence and the group mean using sliding window nucleotide similarity analysis with a 200-nt window moving in 20-nt steps; similarity was not calculated for lineages containing only one sequence.