| Enediyne |
|
PKS16,17
|
Large scale genome mining18,19
|
| β-Lactam |
|
(1) β-Lactam synthetase (β-LS)20
|
Single genome mining24
|
| (2) Carbapenam synthetase (CPS)21
|
| (3) IPNS22
|
| (4) Condensation domain23
|
| β-Lactone |
|
(1) β-Lactone synthetase25,26
|
Large scale genome mining26
|
| (2) Thioesterase (TE)27
|
| (3) Hydrolase28
|
Single genome mining29
|
| Michael acceptor: α,β-unsaturated carbonyl |
|
(1) Terpenes synthase30
|
|
| (2) PKSs31
|
| (3) Hybrid NRPS-PKS32
|
| Epoxyketone |
|
(1) Flavin-dependent decarboxylase–dehydrogenase–monooxygenase33,34
|
Large scale genome mining35
|
| Epoxide |
|
(1) P450 (epothilone)36
|
Single genome mining41
|
| (2) Flavin-dependent epoxidases37
|
Single genome mining42
|
| (3) Dioxygenases (epoxyquinones)38
|
| (4) Non-heme iron-dependent epoxidases (fosfomycin)39,40
|
| Aziridine |
|
Unknown |
|
| Maleimide |
|
(1) Flavin-dependent oxidase43
|
|
| (2) PKS-NRPS44
|
| Sulfonamide/sulfone |
|
(1) Radical-forming, SO2 incorporating flavoprotein45
|
|
| Furan |
|
Terpene oxidation46
|
Large scale genome mining47
|
| Disulfide |
|
(1) FAD-dependent dithiol oxidase (holomycin, gliotoxin, FK228)48–50
|
Single genome mining52
|
| (2) DUF-SH didomain51
|
Large scale genome mining53
|
| Isothiocyanate |
|
Putative isonitrile synthase54
|
Large scale genome mining54
|
| Carbamate |
|
Carbamoyltransferase55
|
|
