FIG 1.

Alignment of different dermatophytes, A. fumigatus, C. albicans, and human (H. sapiens) DHODH amino acid sequences. Identical residues are distinguished by dots, and similar residues are highlighted in gray. The predicted mitochondrial targeting sequences are indicated by the orange line, and the predicted transmembrane domains are shown by the green line. The seven residues predicted to be important for olorofim binding in A. fumigatus DHODH are depicted by arrows, whose colors illustrate conservation status—black, purple, and blue for conserved residues unique to A. fumigatus, Candida, and humans, respectively.