TABLE 3.
Unique mutations in colistin-resistant strains compared to colistin-susceptible strainsa
| Protein mutation/name | GenBank protein accession no. | Mutations in colistin-resistant strains |
|||
|---|---|---|---|---|---|
| A1712 | A1816 | A1820 | A1828 | ||
| pmrAB mutations | |||||
| DNA-binding response regulator PmrA | WP_000161506.1 | L20F (60) | M12I (53, 54, 60) | ||
| Outer membrane proteins | |||||
| Outer membrane beta-barrel protein, OmpW family | WP_000472952.1 | L81F, N82D | L81F, N82D | ||
| OmpA family protein | WP_000777880.1 | E146fs | |||
| Outer membrane porin, OprD family | WP_171059678.1 | P86T | |||
| TonB-dependent receptor | WP_086242031.1 | V443A | |||
| Pilin pilA | WP_000993718.1 | A29Q | |||
| LPS export ABC transporter permease LptF (60) | WP_000586912.1 | R30H | |||
| ABC transporter permease | WP_000096309.1 | H196Y | A41V | ||
| Multidrug efflux MFS transporter AmvA | WP_042791420.1 | Q294L | |||
| LysE family translocator | WP_024437491.1 | G109D | A108L, G109D | A108L, G109D | |
| DMT family transporter | WP_000340904.1 | V293fs | |||
a
STOP codon inserted. fs, frameshift.