Linear regression analysis corrected for age, gender, and parent fatty acid arachidonic acid (AA). 14,15-EET is a cytochrome P450 Omega-6 derived epoxide that is enzymatically transformed to its corresponding diol by sEH to 14,15-DHET; the ratio of 14,15-DHET/14,15-EET is an indirect measure of sEH activity. The ratio of 14,15-DHET/14,15-EET and white matter hyperintensity (WMH) were log transformed. WMH was adjusted for intracranial volume before log transforming. Association Log Ratio 14,15-DHET/14,15-EET and Log WMH (p = 0.045).