Linear regression analysis corrected for age, gender, and parent fatty acid docosahexaenoic acid (DHA). 16,17-EpDPE is a cytochrome P450 Omega-3 derived epoxide. 16,17-EpDPE and white matter hyperintensity (WMH) were log transformed. WMH was adjusted for intracranial volume before log transforming. Association Log Ratio 16,17-EpDPE and Log WMH (p = 0.005).