Linear regression analysis corrected for age, gender, and parent fatty acid docosahexaenoic acid (DHA). 19,20-EpDPE is a cytochrome P450 Omega-3 derived epoxide that is enzymatically transformed to its corresponding diol by sEH to 19,20-DiHDPE; the ratio of 19,20-DiHDPE/19,20-EpDPE is an indirect measure of sEH activity. The ratio of 19,20-DiHDPE/19,20-EpDPE, white matter hyperintensity (WMH), and Trails-B were log transformed. WMH was adjusted for intracranial volume before log transforming. A) Association Log Ratio 19,20-DiHDPE/19,20-EpDPE and Log WMH (p = 0.04). B) Association Log Ratio 19,20-DiHDPE/19,20-EpDPE and Log Trails-B (p = 0.044).