FIG 1.

Activity of bedaquiline (A, B), imipenem (C, D), and imipenem with avibactam (E, F) against M. abscessus ATCC 19977 WT (A, C, E) and OM7 mutant (B, D, F) in CAMHB with 0.05% Tween 80. The change in log₁₀ CFU/ml after 3 days of drug exposure relative to Day 0 is presented for each drug/strain set. Avibactam concentration in panels E and F was 2 μg/ml. +++ indicates bacterial overgrowth and clumping that precluded CFU determination. Avibactam alone at concentrations from 0.5 to 64 μg/ml had no anti-M. abscessus activity; bacteria grew/clumped at all avibactam concentrations, precluding CFU determination. The Day 0 bacterial concentrations (in log₁₀ CFU/ml) for each panel were as follows: A, 5.96; B, 6.11; C, 5.85; D, 5.86; E, 5.85; F, 5.86. CFU values are provided in Table S2.