FIG 2.

Activity of bedaquiline (BDQ) and imipenem (IPM)/avibactam (AVI) combinations against M. abscessus ATCC 19977 WT (A) and OM7 mutant (B) strains in CAMHB with 0.05% Tween 80. The change in log₁₀ CFU/ml after 3 days of drug exposure relative to Day 0 is presented for each drug/strain set. Black bars represent the no-drug control; red bars indicate BDQ-only samples; blue bars represent IPM/AVI-only samples, and gray bars indicate IPM/AVI plus BDQ samples. The number after each drug abbreviation represents the concentration in μg/ml. The Day 0 bacterial concentrations (in log₁₀ CFU/ml) were 5.57 and 5.76 for WT and OM7 mutant strains, respectively. CFU values are provided in Table S3.