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Activity of bedaquiline (A, B) and imipenem (C ,D) against M. abscessus ATCC 19977 WT (A, C) and OM7 mutant (B, D) in CAMHB without Tween 80. The change in log10 CFU/ml after 3 days of drug exposure relative to Day 0 is presented for each drug/strain set. +++ indicates bacterial growth and clumping that precluded CFU determination. The Day 0 bacterial concentrations (in log10 CFU/ml) for each panel were as follows: A, 5.90; B, 5.08; C, 5.91; D, 6.20. CFU values are provided in Table S7.
