FIG 8.

Activity of bedaquiline (BDQ) and imipenem (IPM) against nutrient-starved M. abscessus ATCC 19977 WT in PBS with 0.05% Tween 80. Bacteria were nutrient-starved in PBS for 20 days prior to drug exposure. The changes in log₁₀ CFU/ml after 4 days of drug exposure relative to Day 0 are presented. Red bars indicate BDQ-only samples; blue bars represent IPM-only samples; and gray bars indicate IPM + BDQ samples. The number after the IPM abbreviation represents the concentration in μg/ml; for red and gray bars, the BDQ concentration in μg/ml is under each bar. Data after 1 day of drug exposure, as well as data from a biological replicate, are presented in Fig. S13. The Day 0 bacterial concentration was 6.07 log₁₀ CFU/ml. CFU values are provided in Table S11.