FIG 2.

Distribution of predicted tedizolid AUC_{0–24h_last} (a) and fAUC_{0–24h_last}/MIC (b) in log scale with overall response between cure, failure, and indeterminate at test of cure in the phase 3 PN012 trial in adolescents.^a AUC_{0–24h_last}, area under the concentration-time curve from 0 to 24 hours on the last dosing day; fAUC_{0–24h_last}, area under the concentration-time curve for the free, unbound fraction of the drug from 0 to 24 hours on the last dosing day; MIC, MIC. ^aPharmacokinetic and microbiological data were not available for every participant.