FIG 1.
MK-8507 plasma PK following administration of single oral MK-8507 doses in adults without HIV. (A) Mean plasma concentration versus time profiles of MK-8507 following administration of single oral doses of MK-8507 suspension or tablet in the fasted state in adults without HIV (n = 6/dose level). (B) Individual MK-8507 plasma AUC0–∞, Cmax, and C168hr ratios (fed/fasted) and GMRs with corresponding 90% CIs following the administration of a single oral dose of 100 mg MK-8507 suspension following a high-fat meal or following an overnight fast (n = 6) in adults without HIV. AUC0–∞, area under the concentration-time curve from 0 to infinity; C168hr, trough concentration; CI, confidence interval; Cmax, maximum concentration; GMR, geometric least-squares mean ratio.