TABLE 1.
Genome features and MICs of 15 A. fumigatus strains
| Strain | Size (bp) | No. of scaffolds | N50 (bp) | No. of genes | Repeat region (%) | Cyp51A mutation(s) | MIC (mg/liter)a |
Azole resistance | ||
|---|---|---|---|---|---|---|---|---|---|---|
| ITC | VRC | POS | ||||||||
| C94 | 28,816,918 | 94 | 825,047 | 8,824 | 5.05 | TR34/L98H | ≥16 | 2 | 1 | Resistant |
| C96 | 28,676,732 | 45 | 2,607,325 | 8,921 | 2.29 | TR34/L98H/S297T/F495I | ≥16 | 1 | 0.5 | Resistant |
| C116 | 28,867,951 | 43 | 1,501,208 | 8,871 | 5.23 | TR34/L98H | ≥16 | 4 | 0.5 | Resistant |
| XJ138 | 29,142,407 | 46 | 1,853,060 | 8,907 | 5.09 | TR34/L98H | ≥16 | 2 | 0.5 | Resistant |
| E739 | 28,816,696 | 32 | 1,960,044 | 8,928 | 3.53 | TR34/L98H/S297T/F495I | ≥16 | 2 | 0.5 | Resistant |
| C821 | 29,118,210 | 46 | 1,592,331 | 8,922 | 3.91 | TR34/L98H | ≥16 | 4 | 1 | Resistant |
| C1664 | 28994183 | 66 | 1,169,047 | 8,859 | 4.30 | TR34/L98H | ≥16 | 8 | 1 | Resistant |
| STJ0105 | 29,148,970 | 67 | 1,499,649 | 8,874 | 4.53 | TR34/L98H | ≥16 | 8 | 2 | Resistant |
| C79 | 28,522,771 | 65 | 1,040,756 | 8,798 | 4.27 | D262Y | 0.25 | 0.5 | 0.06 | Sensitive |
| C490 | 28,971,844 | 66 | 2,259,216 | 8,976 | 2.82 | N248K | 1 | 0.25–0.5 | 0.125 | Sensitive |
| E509 | 28,966,977 | 63 | 2,394,484 | 8,984 | 2.99 | N248K | 0.5–1 | 0.25 | 0.06–0.125 | Sensitive |
| E631 | 28,676,852 | 62 | 2,159,055 | 8,917 | 1.90 | None | 0.25 | 0.25–0.5 | 0.125 | Sensitive |
| E691 | 28,758,967 | 88 | 1,247,161 | 8,965 | 1.87 | None | 0.25 | 0.5 | 0.25 | Sensitive |
| E1069 | 28,786,365 | 36 | 3,185,189 | 8,917 | 3.24 | A9T | 0.25–0.5 | 0.5 | 0.125 | Sensitive |
| E1109 | 28,073,344 | 37 | 2,455,631 | 8,772 | 3.16 | None | 0.25 | 0.5 | 0.06 | Sensitive |
a
VRC, voriconazole; POS, posaconazole; ITC, itraconazole.