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Effects of stilbenoids on inhibition of SARS-CoV-2 Mpro activity. (A) Demonstration of recombinant Mpro enzymatic activity on a fluorescence resonance energy transfer (FRET)-based fluorogenic peptide substrate. (B) Dose-response curves of stilbenoids and control inhibitor GC-376 on Mpro enzymatic activity. Results in panel B denote the mean ± SEM from at least 3 independent experiments.
