TABLE 1.
Summary of total stilbenoid and control compound bioactivities in AlphaScreen and pseudovirus assays
| Compound | IC50 for: |
Infected cells at 50 μM (%) |
|||||
|---|---|---|---|---|---|---|---|
| Spike/ACE2 AlphaScreen | PD-1/PD-L1 AlphaScreen (μM) | Selectivity index | Mpro activity (μM) | VSVΔG-S-GFP pseudovirus |
|||
| WA1/2020 | B.1.1.7 | B.1.351 | |||||
| Hopeaphenol | 0.11 μM | 28.3 | 257.3 | 42.5 | 28.2 | 34.1 | 20.4 |
| Vatalbinoside A | 0.24 μM | 22.3 | 92.9 | 68.7 | 40.4 | 43.8 | 41.1 |
| Vaticanol B | 0.067 μM | 16.6 | 247.8 | 47.6 | 83.7 | 37.7 | 72.3 |
| Resveratrol | >100 μM | 96.3 | |||||
| REGN10933 | 0.18 nM | ||||||
| BMS-1166 | >100 μM | 0.0040 | |||||
| GC-376 | 0.0052 | ||||||