Fig. 5. (a) High energy ester C18F-NP undergoes co-assembly with C18H to drive the transient generation of helical morphologies. Hydrolysis of the substrate C18F-NP is accelerated from the assembled state due to cooperative effects and results in disassembly. Structures of the molecules are shown in the box. (b) Time-course kinetics of the hydrolysis of C18F-NP for SYS1 and SYS2 (SYS1 and SYS2 refer to the substrate induced assembly and substrate added after equilibration of the building block respectively). (c) Bar diagram of normalized hydrolytic rates of C18F-NP (left) and PNPA (right) in SYS1 and SYS2. Adapted from ref. 30 with permission from John Wiley and Sons.