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. 2021 Nov 3;11:729887. doi: 10.3389/fonc.2021.729887

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Copyright © 2021 Li, Deng, Pang, Huang, Zhang, Zhu, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical features and transcriptome traits of the m⁵C-associated phenotypes. (A) Alluvial diagram showing the changes of m⁵C modification patterns, gender, age, gene cluster, and the m⁵C-score. (B) DEGs between high and low m⁵C-score samples. (C, D) Differences in DFS (C) and OS (D) between high and low m⁵C-score samples. (E) Relationship between the m⁵C-score value and the score of CD3+CD4+/CD3+CD8+ cells of the peripheral blood samples of 24 GBM patients. The m⁵C-Score value was negatively associated with the ratio of CD3+CD4+/CD3+CD8+ cells. (F) Relationship between the m⁵C-score value and the percentage of CD4+CD25+ Tregs in peripheral blood samples of the 24 GBM patients. The m⁵C-score value was positively related with the percentage of CD4+CD25+ Tregs.