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. 2021 Nov 3;11:729887. doi: 10.3389/fonc.2021.729887

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Copyright © 2021 Li, Deng, Pang, Huang, Zhang, Zhu, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Five potential drugs based on the PTC m5C-score model could impair growth of PTC cells. (A) Histogram showing the viability of PTC cells with or without five potential drugs (cephaeline, emetine, anisomycin, ouabain, and thapsigargin) for 48 h at 20 μM. (B) BALB/c mice were subcutaneously injected with PTC cells. After 5 days, the nude mice were treated with cephaeline, emetine, anisomycin, ouabain, or thapsigargin (100 mg/kg daily, intraperitoneal injection). Tumor weights were measured after 6 weeks (n = 5 mice/group). ***statistical significance.