Table 1.

Clinical characteristics of PA and EH patients.

Clinical factors	PA (n=19)	EH (n=22)	P value
Age (y)	58 (40~75)	67 (53~93)	<0.01^*
Sex (male/female)	14/5	16/6	0.95
eGFR (mL/min/1.73m²) (pre-operative in PA)	68.9 (27.9~105.8)	54.3 (18.3~84.3)
Post-operative eGFR (mL/min/1.73m²)	50.5 (16.8~83.6)		0.70 (compared with EH)
ΔeGFR	−11.7 (−47.1~3.0)
Duration of hypertension (y)	15 (2~36)	14 (2~33)	0.73
Number of antihypertensive agents (n)	2 (0~6)	1 (0~2)	0.02^*
Body Mass Index (kg/mm²)	25.7 (18.5~30.2)	23.9 (15.8~28.5)	0.10
Past history of diabetes (+/−)	3/13	5/17	0.77
Systolic blood pressure (mmHg) ^†	150 (138~183)	130 (123~206)	0.01^*
Diastolic blood pressure (mmHg) ^†	88 (60~103)	80 (59~123)	0.15
Serum potassium level (mM) ^†	3.5 (2.7~4.5)	4.4 (3.1~5.9)	0.02^*
Potassium replacement (mmol/d) ^†	36.0 (3.6~156)	NA
Plasma Aldosterone Concentration (ng/dl)	47.7 (12.2~244.6)	NA
Plasma Renin Activity (ng/ml/h)	0.48±0.9 (0.1~0.8)	NA
Aldosterone-Renin Ratio	345.7±1109 (15.3~2446)	NA
Serum cortisol (μg/dl) on 1mg dexamethasone suppression test^†	1.1 (0.6~2.0)	NA
Urine Albumin-to-Creatinine Ratio^†	85.2 (5.6~838.8)	NA
Urinary Potassium (mmol/d) ^†	65.2 (20.4~108.5)	NA
Urinary Sodium (mmol/d) ^†	88.0 (67.0~325.5)	NA
Urinary Aldosterone (μg/d) ^†	25.3 (4.4~374.5)	NA

Median of each parameters was written in this table. eGFR of EH cases were matched with post-operative eGFR of PA. The age of the patients was lower and the number of antihypertensive agents was higher in PA than in EH. PA patients also had higher systolic blood pressure and lower serum K level.

^†

included only 11 cases from Tohoku University Hospital. PA; primary aldosteronism, EH; essential hypertension, eGFR; estimated glomerular filtration rate. (The Mann-Whitney U test and the chi-squared test for gender difference.)

Median (range)

p<0.05