Table 3.
Correlations of clinicopathological findings in PA.
| Factors | PAC | PRA | ARR | APA H score | Serum K | K replacement | U-K | U-Na | UACR | Post-operative eGFR |
| GGS | ρ= 0.2000 p= 0.56 |
ρ= −0.5001 p= 0.12 |
ρ= 0.3455 p= 0.30 |
ρ= −0.0061 p= 0.99 |
ρ= 0.3562 p= 0.28 |
ρ= −0.7335
p= 0.01 |
ρ= 0.1185 p= 0.73 |
ρ= 0.6091
p= 0.05 |
ρ= 0.1455 p= 0.67 |
ρ= −0.7091
p= 0.02 |
| SGS | ρ= −0.2877 p= 0.39 |
ρ= 0.4652 p= 0.15 |
ρ= −0.5708 p= 0.07 |
ρ= −0.1459 p= 0.69 |
ρ= 0.3280 p= 0.32 |
ρ= 0.4874 p= 0.13 |
ρ= 0.0123 p= 0.97 |
ρ= −0.1324 p= 0.70 |
ρ= −0.2831 p= 0.40 |
ρ= 0.2006 p= 0.58 |
| SGS/GGS | ρ= −0.4795 p= 0.14 |
ρ= 0.5439 p= 0.09 |
ρ= −0.6347
p= 0.04 |
ρ= −0.1033 p= 0.78 |
ρ= 0.1881 p= 0.58 |
ρ= 0.7117
p= 0.01 |
ρ= 0.0510 p= 0.88 |
ρ= −0.2466 p= 0.46 |
ρ= −0.2420 p= 0.47 |
ρ= 0.5410 p= 0.11 |
| Glomerular size | ρ= 0.0364 p= 0.92 |
ρ= 0.5093 p= 0.11 |
ρ= −0.3091 p= 0.36 |
ρ= 0.3455 p= 0.30 |
ρ= −0.1416 p= 0.68 |
ρ= 0.0592 p= 0.86 |
ρ= 0.2627 p= 0.41 |
ρ= −0.0909 p= 0.79 |
ρ= 0.7455
p< 0.01 |
ρ= 0.3091 p= 0.38 |
| Interstitial fibrosis | ρ= 0.0727 p= 0.83 |
ρ= 0.1019 p= 0.77 |
ρ= 0.0000 p= 1.00 |
ρ= −0.1394 p= 0.70 |
ρ= −0.3543 p= 0.09 |
ρ= 0.0228 p= 0.95 |
ρ= 0.2382 p= 0.46 |
ρ= −0.2182 p= 0.52 |
ρ= 0.1727 p= 0.61 |
ρ= 0.5273 p= 0.12 |
| Inflammation | ρ= 0.2182 p= 0.52 |
ρ= −0.0648 p= 0.85 |
ρ= 0.1818 p= 0.59 |
ρ= 0.0909 p= 0.80 |
ρ= 0.3836 p= 0.24 |
ρ= −0.5695 p= 0.07 |
ρ= 0.3554 p= 0.28 |
ρ= 0.0545 p= 0.87 |
ρ= 0.4182 p= 0.20 |
ρ= −0.5030 p= 0.14 |
| Luminal stenosis | ρ= 0.3455 p= 0.33 |
ρ= −0.6648
p= 0.04 |
ρ= 0.5030 p= 0.14 |
ρ= −0.2333 p= 0.55 |
ρ= 0.0732 p= 0.84 |
ρ= −0.7295
p= 0.02 |
ρ= −0.0820 p= 0.81 |
ρ= 0.5515 p= 0.10 |
ρ= −0.0788 p= 0.83 |
ρ= −0.4667 p= 0.21 |
| IMR | ρ= 0.0909 p= 0.80 |
ρ= −0.3293 p= 0.35 |
ρ= 0.1394 p= 0.70 |
ρ= 0.2667 p= 0.49 |
ρ= 0.4146 p= 0.23 |
ρ= −0.3343 p= 0.35 |
ρ= −0.1367 p= 0.69 |
ρ= 0.3333 p= 0.35 |
ρ= 0.2727 p= 0.45 |
ρ= −0.5000 p= 0.17 |
| Hy | ρ= −0.1727 p= 0.61 |
ρ= 0.0556 p= 0.87 |
ρ= 0.0091 p= 0.98 |
ρ= 0.0303 p= 0.93 |
ρ= −0.1050 p= 0.76 |
ρ= −0.2916 p= 0.38 |
ρ= −0.2172 p= 0.50 |
ρ= 0.0545 p= 0.87 |
ρ= 0.3636 p= 0.27 |
ρ= 0.0061 p= 0.99 |
| Hy-af | ρ= −0.0578 p= 0.87 |
ρ= 0.0294 p= 0.93 |
ρ= −0.1387 p= 0.68 |
ρ= 0.2312 p= 0.52 |
ρ= 0.5866 p= 0.06 |
ρ= −0.0348 p= 0.92 |
ρ= −0.0646 p= 0.84 |
ρ= 0.1445 p= 0.67 |
ρ= 0.7862
p< 0.01 |
ρ= −0.4250 p= 0.22 |
| Hy-ef | ρ= −0.3337 p= 0.32 |
ρ= −0.1457 p= 0.67 |
ρ= −0.0477 p= 0.89 |
ρ= 0.3439 p= 0.33 |
ρ= 0.7711
p< 0.01 |
ρ= −0.1003 p= 0.77 |
ρ= 0.3047 p= 0.34 |
ρ= 0.1335 p= 0.70 |
ρ= 0.4672 p= 0.15 |
ρ= −0.6941
p= 0.03 |
| 11βHSD2 | ρ= 0.4000 p= 0.22 |
ρ= 0.2686 p= 0.42 |
ρ= 0.0000 p=1.00 |
ρ= 0.4909 p= 0.15 |
ρ= −0.2922 p= 0.38 |
ρ= 0.0000 p= 1.00 |
ρ= 0.2907 p= 0.36 |
ρ= 0.3909 p= 0.23 |
ρ= 0.2545 p= 0.45 |
ρ= −0.0909 p= 0.80 |
| 11βHSD2/11βHSD1 | ρ= −0.0182 p= 0.96 |
ρ= 0.3890 p= 0.24 |
ρ= −0.2364 p= 0.48 |
ρ= −0.0667 p= 0.85 |
ρ= −0.1918 p= 0.57 |
ρ= −0.1913 p= 0.57 |
ρ= −0.1086 p= 0.74 |
ρ= −0.0636 p= 0.85 |
ρ= 0.3636 p= 0.27 |
ρ= 0.1273 p= 0.73 |
| Renin | ρ= −0.2288 p= 0.50 |
ρ= 0.0194 p= 0.95 |
ρ= −0.1335 p= 0.70 |
ρ= −0.2376 p= 0.51 |
ρ= −0.1676 p= 0.62 |
ρ= 0.3631 p= 0.27 |
ρ= −0.0182 p= 0.96 |
ρ= 0.1430 p= 0.67 |
ρ= −0.6293
p= 0.04 |
ρ= 0.4502 p= 0.19 |
| MR | ρ= 0.2605 p= 0.44 |
ρ= −0.4834 p= 0.13 |
ρ= 0.4280 p= 0.19 |
ρ= 0.1751 p= 0.63 |
ρ= 0.2757 p= 0.4118 |
ρ= −0.7787
p< 0.01 |
ρ= 0.2959 p= 0.35 |
ρ= 0.7909
p< 0.01 |
ρ= 0.3396 p= 0.31 |
ρ= −0.7754
p< 0.01 |
| Pre-operative eGFR | ρ= 0.3818 p= 0.25 |
ρ= −0.3149 p= 0.35 |
ρ= 0.2909 p= 0.39 |
ρ= 0.1030 p= 0.78 |
ρ= −0.4110 p= 0.21 |
ρ= 0.3235 p= 0.33 |
ρ= −0.1686 p= 0.62 |
ρ= −0.1091 p= 0.75 |
ρ= −0.6000 p= 0.05 |
ρ= 0.4061 p= 0.24 |
Comparison among clinicopathological parameters of renal injury and aldosterone-producing ability in PA patients. Relatively higher aldosterone concentration to renin was inversely correlated with SGS/GGS ratio. U-Na was significant correlated with GGS and MR positivity. UACR was correlated with glomerular size and Hy-af. GGS, Hy-ef and MR positivity directly reflected decrease of post-operative eGFR.
PAC; plasma aldosterone concentration, PRA; plasma renin activity, ARR; aldosterone-to-renin ratio, eGFR; estimated glomerular filtration rate, GGS; global glomerular sclerosis, SGS; segmental glomerular sclerosis, IMR; intima-to-media ratio, Hy; arteriolar hyalinization, Hy-af; afferent arteriolar hyalinization, Hy-ef; efferent arteriolar hyalinization, 11βHSD; 11-beta hydroxysteroid dehydrogenase, MR; mineralocorticoid receptor, K; potassium, Na; sodium, U; urinary, UACR; urinary albumin-to-creatinine ratio. (The Spearman’s rank test was used.)