Table 1:
Homology analysis of CA215 based on MALDI-TOF MS analysis of tryptic peptides
| Molecule function/Category | Number of peptides matcheda Total = 124 (Percentage) |
|---|---|
| I. Antigen receptors | |
| 1. Antibodies and immunoglobulins | 52 (42.0%) |
| 2. T-cell receptor chains | 7 (5.7%) |
| II. Antigen-presenting molecules (MHC I and MHC II) | 6 (4.9%) |
| III. Adhesion molecules | 10 (8.1%) |
| IV. Cytokine and growth factors | 8 (6.5%) |
| V. Receptor tyrosine kinase/phosphatase | 7 (5.7%) |
| VI. Others | |
| 1. IgSF related (e.g., titin) | 12 (9.7%) |
| Total with homologyb: 75/124 (60.5%) | |
| 2. IgSF unrelated (e.g., mucin) | 9 (7.3%) |
a
Acid-eluted CA215 (lots CA215A and CA215B) was used for MALDI-TOF MS analysis with MASCOT Program from http://www.matrixscience.com.
b
Excluding overlapping matched peptides.