Table 3:
Comparative profiles of permethylated O-linked glycans of five different CA215 samples
| Sample ID | Observed mass m/z [M+Na]+ | Proposed structure | Structure |
|---|---|---|---|
| CA215 (lots: A, B, and C)a | 534 | GalNAc1Gal1 |
C
|
| CA215 (lots: A and B) | 708 | GalNAc1Gal1Fuc1 |
|
| CA215 (lots: A, B, D, C, E, and F)b | 896 | GalNAc1Gal1NeuAc1 |
|
| CA215 (lots: C, E, and F) | 926 | GalNAc1Gal1 NeuGc1 |
|
| CA215C | 940d | GalNAc1GlcNAc1NeuAc1 |
|
| CA215 (lots: A, B, and C) | 1140 | GalNAc1GlcNAc1Gal1NeuAc1 |
|
| CA215 (lots: C, D, E, and F) | 1257 | GalNAc1Gal1NeuAc2 |
|
| CA215 (lots: C, E, and F) | 1317 | GalNAc1Gal1NeuGc2 |
|
| CA215 (lots: A, B, C, E, and F) | 1345 | GalNAc1GlcNAc1Gal2NeuAc1 |
|
| CA215 (lots: C, E, and F) | 1375 | GalNAc1GlcNAc1Gal2NeuGc1 |
|
CA215 lots A, B, and C were from OC-3-VGH ovarian cancer cells (CA215-OC-3); lots A and B were obtained through acid elution, whereas lots C, D, E, and F were obtained through elution with 3 M urea.
Lot CA215D was obtained by an additional purification of urea-eluted CA215 (S15K-100425) with goat antihuman IgG affinity column followed by the same analysis. CA215 lots E and F were from C-33A cervical cancer cells (CA215-C33A).
N-acetylgalactosamine (□), N-acetylglucosamine (■), Fucose (▲), Galactose (
), N-acetylneuraminic acid (
), and N-glycolylneuraminic acid (
).
Detected by MALDI-TOF MS method but not found by NSI-MS method.