FIG. 3.

PAP contains a CRM. A schematic representation of PAP is shown at the top. The cyclin recognition motif is boxed and striped, and the Ser-Thr-rich regulatory region is boxed in black, with white bars representing the cdk sites and gray bars representing the nuclear localization sequences. An alignment of CRMs with the highly conserved arginine and leucine residues highlighted is shown below. The CRM consensus contains the nearly invariant arginine and leucine residues and, in lowercase, the residues found most frequently at the other positions.