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. 2021 Nov 17;7(47):eabg9551. doi: 10.1126/sciadv.abg9551

Fig. 3. Prognostic implications of gain(1q), tMMSET, and gain(15q).

Fig. 3.

(A and B) Survival plots show that 1q gain identifies a subset of HD patients with significantly shorter PFS and OS. (C and D) Survival plots show that patients with 1q gain with or without tMMSET have poorer outcome than patients with tMMSET alone. (E and F) Gain of 15q is associated with better PFS and OS. (G and H) Survival plots show that patients with 1q gain that received autologous stem cell transplant (ASCT) have significantly better PFS and OS compared to patients that did not receive ASCT. (I and J) Gain of 1q significantly stratifies risk for relapse and mortality in patients in International Staging System (ISS) classes I and III and risk of mortality in patients in ISS class II. (K and L) Gain of 1q significantly stratifies risk for relapse and mortality in patients in revised ISS (rISS) class II and risk of mortality in patients in rISS class III. P values were calculated using the log-rank test.