Table 1. IC50 of G6PDi-1 with supplement of CB-839 in mouse cell lines (n = 4).
| G6PDi-1 IC50 (μM) | CB-839 (nM) | ||
| 0 | 6 | 12 | |
| WT | 70 | 44.41 | 40.405 |
| WT + Nrf2 activator | 50.65 | 31.315 | 24.9 |
| KO + vector | 42.08 | 30.09 | 24.98 |
| KO + Keap1 WT | 80.05 | 46.9 | 36.595 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.