Fig 5. Escape from both neutralization and ADCC responses in two CAPRISA 002 participants.

Neutralizing and ADCC responses were evaluated against wildtype and mutant viruses where putative ADCC or nAbs escape mutations were introduced into the autologous CAP45 or CAP210 T/F Env-IMCs. The impact of each mutation on sensitivity to autologous nAb and ADCC responses was then tested using longitudinal plasma. (A) Effect of the D462G mutation on neutralization and ADCC responses in CAP45; (B) Effect was A161V and V208I mutations on nAb and ADCC responses. Points on ADCC and neutralisation plots indicate the mean of ≥three independent experiments.