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. 2021 Jun 3;45(12):1669–1681. doi: 10.1097/PAS.0000000000001748

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/

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EWSR1-NFATC2 translocation identified in the endothelial lining as well as the surrounding spindle cells in vascular malformation/hemangioma. EWSR1-NFATC2 colocalization FISH (B, C) and corresponding area in hematoxylin and eosin section (A) in L6952 (case 1) highlights the presence of the fusion in the endothelial lining. Yellow arrows marking fusion cells. Scoring of EWSR1-NFATC2 FISH in case 2 for the lining cells (D, E) and the surrounding spindle cells (F, G). Red boxes represent cells with colocalization of the EWSR1 and NFATC2 probe, while white boxes represent normal cells.