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. 2021 Nov 11;10:e71077. doi: 10.7554/eLife.71077

Figure 3. Effects of Judgement type and drug on parametric striatal connectivity.

Figure 3.

(A) On wanting trials (collapsed across drug groups), dorsolateral prefrontal cortex (DLPFC)-striatum connectivity was enhanced for wanting relative to liking aspects of rewards (image thresholded at p < 0.001 uncorrected). (B) Wanting-related DLPFC-striatum coupling was significantly stronger under naltrexone compared with placebo (image thresholded at p < 0.001 uncorrected). (C, D) Extracted parameter estimates for DLPFC (as defined by the significant cluster in general linear model 1 [GLM-1]), separately for wanting and liking judgements. (C) If wanting judgements were behaviorally relevant, naltrexone increased wanting relative to liking-related DLPFC-striatum connectivity. (D) No significant drug effects on DLPFC-striatum connectivity were observed on liking trials. Error bars indicate standard error of the mean, black dots represent individual data points. *p < 0.05.