Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 7;24(11):907–919. doi: 10.1093/ijnp/pyab055

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — AICP increase excitatory neurotransmission in basolateral amygdala (BLA) neurons. (A) Whole cell voltage clamp recordings from BLA neurons were conducted in WT and GluN2C KO mice. A significant increase in the frequency of mEPSC was observed following bath application of AICP in WT mice (WT-baseline 100.117 ± 2.021 vs WT-1µM AICP 153.415 ± 15.345, P = .0016; two-way ANOVA with Bonferroni’s post hoc test). No significant differences were observed in amplitude of mEPSCs following AICP treatment (P > .05). AICP failed to produce any significant effect on mEPSC frequency and amplitude in GluN2C KO mice (P > .05). Data are represented as mean ± SEM. (B) Immunohistochemical analysis in Grin2C^EGFP-CreERT2 (GluN2C KO) mouse model. The coronal sections passing through BLA were immunolabelled for eGFP (GluN2C) and GFAP. Expression of eGFP in the Grin2C-reporter model was found to primarily co-localize with astrocytic marker GFAP.