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. 2021 Aug 2;24(11):894–906. doi: 10.1093/ijnp/pyab053

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© The Author(s) 2021. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Prepulse inhibition (PPI) of the acoustic startle response (ASR). PPI is the process by which the ASR to a sudden high-intensity stimulus (top) is substantially reduced when that stimulus is immediately preceded by a much lower intensity, non-startling stimulus (bottom). Stimulus onset and magnitude of these two conditions is indicated at left, with background noise levels represented by horizontal dotted lines. Response magnitude is indicated at right (arbitrary units). PPI is reported as percent decrement of the ASR and is calculated using the average ASR magnitudes elicited by prepulse-paired (bottom) and unpaired (top) high intensity stimuli.