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. 2021 Nov 10;2021:9046798. doi: 10.1155/2021/9046798

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Copyright © 2021 Hongyu Wan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

LINC00665 targeted miR-214-3p/MAPK1. (a) starBase database showed that MAPK1 was overexpressed in HCC tissues. (b, c) Pearson analysis of the association between the expression levels of LINC00665 and miR-214-3p in 50 HCC tissues. (d) Binding sites of miR-214-3p and MAPK1. (e, f) Luciferase gene reporter and RIP assay were applied to assess the crosstalk between LINC00665 and miR-214-3p. (g, h) MAPK1 expression in SNU-423 cells was measured by qRT-PCR assay. (i) The expressions of p-p38 MAPK and MAPK1 were determined by western blotting (n = 3, ∗p < 0.05 versus control group; #p < 0.05 versus lentiv-LINC00665 group).