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. 2021 Nov 10;2021:9154406. doi: 10.1155/2021/9154406

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Copyright © 2021 Netish Kumar Kundo et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cholinesterase inhibitory activities of the extract and fractions from L. globosus. (a) Inhibition of AChE. IC₅₀ (μg/ml): CME, 153.767 ± 2.409; PEF, 123.367 ± 0.306; CLF, 171.533 ± 5.478; EAF, 64.987 ± 0.669; AQF, 87.417 ± 0.610; DON, 8.351 ± 0.076. (b) Inhibition of BChE. IC₅₀ (μg/ml): CME, 155.733 ± 0.907; PEF, 353.633 ± 3.408; CLF, 391.633 ± 4.561; EAF, 85.270 ± 0.982; AQF, 129.267 ± 1.002; GAL, 8.208 ± 0.105. Results are expressed as mean ± SD (n = 3). Means with different letters (a-f) differ significantly (P < 0.05). CME: crude methanolic extract; PEF: petroleum ether fraction; CLF: chloroform fraction; EAF: ethylacetate fraction; AQF: aqueous fraction; AChE: acetylcholinesterase; BChE: butyrylcholinesterase; DON: donepezil; GAL: galantamine.