Figure 5.

The effect of XN and DPI on ROS generation in RBCs. Human RBCs lack mitochondria while having NOX. (a, c, e) Representative flow cytometry histograms show dose- and time-dependent effect of XN on ROS in RBCs and the effect of DPI, respectively. (b, d, f) The related statistical results, respectively. RBCs were treated with XN for 1 h in (a, b, e, f), and the XN concentration used in (c–f) was 160 μM (n = 3, ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001 vs. control group; ##p < 0.01 “XN vs. XN+DPI”).